Endocrine Abstracts

The melanocortin system is significant for energy homeostasis and receptors have distinct tissue specific expression. The melanocortin 2-receptor (Mc2r) transmits ACTH dependent signalling in the adrenal cortex. Increased expression in adipocytes during differentiation indicates relevance for lipid homeostasis. Mc2r activation in adipocytes results in increased lipolysis, however, implication compared to norepinephrine (NE) stimulated lipolysis is unknown. To further define fu...

Rationale: Endothelial dysfunction (ED) is a hallmark of primary aldosteronism and paves the way for subsequent atherosclerotic disease. Past research has confirmed that one factor involved in ED is disturbed nitric oxide (NO) signalling. Since defects in NO release alone cannot explain the whole effect, we set out to address the role of endothelial CYP-expoygenase products (epoxyeicosatrienoic acids, EETs) in aldosterone-mediated endothelial dysfunction.<p class="abstext"...